From the CS6 FAQ:
Adobe and Apple have worked closely together to test Adobe® Creative Suite® 5, 5.5 and CS6 editions and individual products for reliability, performance and user experience when installed on Intel® based systems running Mac OS X Mountain Lion (v10.8). Earlier versions of Adobe Photoshop® (CS3 and CS4) software were also tested with Mountain Lion and there are currently no known issues.
As with any new release of an operating system, there may be unexpected issues that arise that were not discovered during testing. If you encounter any issues, please report them on our bug reporting form.
Video team member Todd Kopriva notes,
Mountain Lion (Mac OS v10.8) upgrade improves performance and stability with Premiere Pro. Be sure to check for drivers for third-party I/O hardware and such, which may not yet be available for your accessories.”