I’m no 3D artist (had I but world enough and time…), but I sure love their work & anything that makes it faster and easier. Perhaps my most obscure point of pride from my Photoshop years is that we added per-layer timestamps into PSD files, so that Pixar could more efficiently render content by noticing which layers had actually been modified.
Anyway, now that Adobe has made a much bigger bet on 3D tooling, it’s great to see new support for Substance Painter coming to Unreal Engine:
The Substance 3D plugin (BETA) enables the use of Substance materials directly in Unreal Engine 5 and Unreal Engine 4. Whether you are working on games, visualization and or deploying across mobile, desktop, or XR, Substance delivers a unique experience with optimized features for enhanced productivity.
Work faster, be more productive: Substance parameters allow for real-time material changes and texture updates.
Substance 3D for Unreal Engine 5 contains the plugin for Substance Engine.
Access over 1000 high-quality tweakable and export-ready 4K materials with presets on the Substance 3D Asset library. You can explore community-contributed assets in the community assets library.
The Substance Assets platform is a vast library containing high-quality PBR-ready Substance materials and is accessible directly in Unreal through the Substance plugin. These customizable Substance files can easily be adapted to a wide range of projects.

For UE5, there’s also this being dev’d:
https://youtu.be/QKVe2Djnk4U